Endocrine Abstracts

The majority of pregnancy steroids originate in the fetal zone of the fetal adrenal (FZ). The data in the literature indicates that placental CRH directly stimulates the FZ. Despite the substantial alterations in the placental CRH production in late pregnancy, the predictivity of CRH for an estimation of term is poor. To sidetrack the expensive determination of unstable CRH, it may be expediential to use the FZ steroids. However, even these substances may not be optimal for pr...

Introduction: MicroRNAs (miRNA) are noncoding RNAs that play a central role in governing a variety of physiological and pathological processes, and there are few studies on miR involvement in diabetes mellitus. There are three principal types of diabetes, i.e., type 1 (T1DM), type 2 (T2DM) and gestational diabetes mellitus (GDM). In this study we performed a meta-analysis of the miRNA expression profiling of peripheral blood mononuclear cells (PBMC) from T1DM, T2DM and GDM pat...

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter primarily produced by neurons and pancreatic beta cells. GABA functional receptors (GABR) are expressed in brain, pancreas and peripheral blood lymphomononuclear cells (PBMC). After evaluating the differential gene expression in PBMC of recently diagnosed type 1 diabetes mellitus patients (T1D), three GABRA networks were observed, modulating the expression dozen of genes. The study was conducted on T (CD4+ a...

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently, it was demonstrated that SOAT1 inhibition leads to impaired steroidogenesis ...